abstract：:A recent systematic synthesis of qualitative research demonstrated that patients with psychogenic nonepileptic seizures (PNES) often experience unsatisfactory encounters with health care practitioners (HCPs). It is important to understand such interactions from the perspective of those responsible for delivering care....

journal_title：Epilepsia

authors： Rawlings GH,Reuber M

更新日期：2018-06-01 00:00:00

abstract：:Status epilepticus (SE) is typically defined as a prolonged self-sustaining seizure or repeated seizures showing an incomplete recovery between them. SE represents a medical emergency often associated with significant disability, morbidity, and mortality. Despite the clinical impact, the mechanisms underlying the tran...

journal_title：Epilepsia

authors： Leo A,Giovannini G,Russo E,Meletti S

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Common data elements (CDEs) are currently unavailable for mobile health (mHealth) in epilepsy devices and related applications. As a result, despite expansive growth of new digital services for people with epilepsy, information collected is often not interoperable or directly comparable. We aim to correct thi...

journal_title：Epilepsia

authors： Goldenholz DM,Moss R,Jost DA,Crone NE,Krauss G,Picard R,Caborni C,Cavazos JE,Hixson J,Loddenkemper T,Salazar TD,Lubbers L,Harte-Hargrove LC,Whittemore V,Duun-Henriksen J,Dolan E,Kasturia N,Oberemk M,Cook MJ,Lehmkuhl

更新日期：2018-05-01 00:00:00

abstract：:Sudden unexpected death of an individual with epilepsy can pose a challenge to death investigators, as most deaths are unwitnessed, and the individual is commonly found dead in bed. Anatomic findings (eg, tongue/lip bite) are commonly absent and of varying specificity, thereby limiting the evidence to implicate epilep...

journal_title：Epilepsia

authors： Middleton O,Atherton D,Bundock E,Donner E,Friedman D,Hesdorffer D,Jarrell H,McCrillis A,Mena OJ,Morey M,Thurman D,Tian N,Tomson T,Tseng Z,White S,Wright C,Devinsky O

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To determine the frequency and predictors of return to driving within 1 year after a diagnosis of epilepsy. METHODS:SEISMIC (the Sydney Epilepsy Incidence Study to Measure Illness Consequences) was a prospective, multicenter, community-wide study of people of all ages with newly diagnosed epilepsy in Sydney,...

journal_title：Epilepsia

authors： Xu Y,Hackett ML,Glozier N,Nikpour A,Somerville E,Bleasel A,Ireland C,Anderson CS

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the influence of prior use of carbamazepine (CBZ) and other antiepileptic drugs (AEDs) with a putatively similar mechanism of action (inhibition of voltage-gated sodium channels; VGSCs) on seizure outcomes and tolerability when converting to eslicarbazepine acetate (ESL), using data pooled from 2 ...

journal_title：Epilepsia

authors： Pazdera L,Sperling MR,Harvey JH,Sam MC,Strom LA,Blum D,Grinnell T,Cheng H

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Epilepsy is characterized by transient alterations in brain synchronization resulting in seizures with a wide spectrum of manifestations. Seizure severity and risks for patients depend on the evolution and spread of the hypersynchronous discharges. With standard visual inspection and pattern classification, t...

journal_title：Epilepsia

authors： Donos C,Maliia MD,Dümpelmann M,Schulze-Bonhage A

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:To compare surgical outcome in mesial temporal lobe epilepsy (MTLE) patients with unilateral hippocampal sclerosis (MTLE-HS) who had or did not have preoperative video-electroencephalographic monitoring (VEEG). METHODS:A prospective study was undertaken with 166 consecutive pharmacoresistant unilateral MTLE-...

journal_title：Epilepsia

authors： Alvim MKM,Morita ME,Yasuda CL,Damasceno BP,Lopes TM,Coan AC,Ghizoni E,Tedeschi H,Cendes F

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Among children with epilepsy, to develop and evaluate a model to predict emergency department (ED) use, an indicator of poor disease control and/or poor access to care. METHODS:We used electronic health record data from 2013 to predict ED use in 2014 at 2 centers, benchmarking predictive performance against ...

journal_title：Epilepsia

authors： Grinspan ZM,Patel AD,Hafeez B,Abramson EL,Kern LM

更新日期：2018-01-01 00:00:00

abstract：:Although the epilepsy and neurology communities have position papers on a number of topics pertaining to epilepsy diagnosis and management, no current paper exists for the rationale and appropriate indications for epilepsy monitoring unit (EMU) evaluation. General neurologists, hospital administrators, and insurers al...

journal_title：Epilepsia

authors： Shih JJ,Fountain NB,Herman ST,Bagic A,Lado F,Arnold S,Zupanc ML,Riker E,Labiner DM

更新日期：2018-01-01 00:00:00

abstract：:The endocannabinoid system has gained attention as an important modulator of activity in the central nervous system. Initial studies focused on cannabinoid receptor 1 (CB1), which is widely expressed in the brain, but recent work also implicates cannabinoid receptor 2 (CB2) in modulating neuronal activity. Both recept...

journal_title：Epilepsia

authors： Rowley S,Sun X,Lima IV,Tavenier A,de Oliveira ACP,Dey SK,Danzer SC

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the long-term seizure outcome and potential factors associated with seizure outcome in patients with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. METHODS:In the setting of a prospective, single-center, longitudinal cohort study, 109 patients were evaluated with ongoing follow-up....

journal_title：Epilepsia

authors： Liu X,Yan B,Wang R,Li C,Chen C,Zhou D,Hong Z

更新日期：2017-12-01 00:00:00

abstract：:Electroencephalography (EEG)-the direct recording of the electrical activity of populations of neurons-is a tremendously important tool for diagnosing, treating, and researching epilepsy. Although standard procedures for recording and analyzing human EEG exist and are broadly accepted, there are no such standards for ...

journal_title：Epilepsia

authors： Moyer JT,Gnatkovsky V,Ono T,Otáhal J,Wagenaar J,Stacey WC,Noebels J,Ikeda A,Staley K,de Curtis M,Litt B,Galanopoulou AS

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Approximately 25 million individuals older than age 15 identify as transgender, representing about 0.3-0.9% of the world's population. The aim of this paper is to identify and describe important medical and social considerations facing transgender persons with epilepsy. METHODS:We performed literature search...

journal_title：Epilepsia

authors： Johnson EL,Kaplan PW

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate changes in health care resource utilization following the initiation of perampanel for the treatment of epilepsy in the United States. METHODS:Health care claims from Symphony Health's Integrated Dataverse database between December 2012 and November 2015 were analyze...

journal_title：Epilepsia

authors： Faught E,Laliberté F,Wang Z,Barghout V,Haider B,Lejeune D,Germain G,Choi J,Wagh A,Duh MS

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Although the general utility of voxel-based processing of structural magnetic resonance imaging (MRI) data for detecting occult lesions in focal epilepsy is established, many differences exist among studies, and it is unclear which processing method is preferable. The aim of this study was to compare the abil...

journal_title：Epilepsia

authors： Martin P,Winston GP,Bartlett P,de Tisi J,Duncan JS,Focke NK

更新日期：2017-09-01 00:00:00

abstract：:Patients with epilepsy have 20-fold risk of sudden death when compared to the general population. Uncontrolled seizures is the most consistent risk factor, and death often occurs at night or in relation to sleep. We examined seizure-related respiratory disturbances in sleep versus wakefulness, focusing on periictal ox...

journal_title：Epilepsia

authors： Latreille V,Abdennadher M,Dworetzky BA,Ramel J,White D,Katz E,Zarowski M,Kothare S,Pavlova M

更新日期：2017-09-01 00:00:00

abstract：:Differentiation between psychogenic nonepileptic seizures (PNES) and generalized convulsive epileptic seizures (ES) is important for appropriate triaging in the emergency department (ED). This can be difficult in the ED, as the event is often not witnessed by a medical professional. In the current study, we investigat...

journal_title：Epilepsia

authors： Li Y,Matzka L,Maranda L,Weber D

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:To investigate the occurrence of ictal and postictal aphasia in different focal epilepsy syndromes. METHODS:We retrospectively analyzed the video-electroencephalographic monitoring data of 1,118 patients with focal epilepsy for seizure-associated aphasia (SAA). Statistical analysis included chi-square analys...

journal_title：Epilepsia

authors： Loesch AM,Steger H,Losher C,Hartl E,Rémi J,Vollmar C,Noachtar S

更新日期：2017-09-01 00:00:00

abstract：:Recent clinical trials indicate that cannabidiol (CBD) may reduce seizure frequency in pediatric patients with certain forms of treatment-resistant epilepsy. Many of these patients experience significant impairments in quality of life (QOL) in physical, mental, and social dimensions of health. In this study, we measur...

journal_title：Epilepsia

authors： Rosenberg EC,Louik J,Conway E,Devinsky O,Friedman D

更新日期：2017-08-01 00:00:00

abstract：:Epileptogenic networks are defined by the brain regions involved in the production and propagation of epileptic activities. In this review we describe the historical, methodologic, and conceptual bases of this model in the analysis of electrophysiologic intracerebral recordings. In the context of epilepsy surgery, the...

journal_title：Epilepsia

authors： Bartolomei F,Lagarde S,Wendling F,McGonigal A,Jirsa V,Guye M,Bénar C

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:To describe the developmental trajectories of quality of life (QoL) in a large cohort of children with epilepsy, and to assess the relative contribution of clinical, psychosocial, and sociodemographic variables on QoL trajectories. METHODS:Five assessments during a 28-month prospective cohort study were used...

journal_title：Epilepsia

authors： Ferro MA,Avery L,Fayed N,Streiner DL,Cunningham CE,Boyle MH,Lach L,Glidden G,Rosenbaum PL,Ronen GM,QUALITÉ group.

更新日期：2017-07-01 00:00:00

abstract：:Epilepsy can be a devastating disorder. In addition to debilitating seizures, epilepsy can cause cognitive and emotional problems with reduced quality of life. Therefore, the major aim is to prevent the disorder in the first place: identify, detect, and reverse the processes responsible for its onset, and monitor and ...

journal_title：Epilepsia

authors： Koepp MJ,Årstad E,Bankstahl JP,Dedeurwaerdere S,Friedman A,Potschka H,Ravizza T,Theodore WH,Baram TZ

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:To examine whether psychiatric comorbidity is a predictor of long-term seizure outcome following temporal lobe epilepsy surgery. METHODS:A sample of 434 adult patients who received temporal lobe resection to treat epilepsy between 1991 and 2009 and were psychiatrically assessed before surgery were followed f...

journal_title：Epilepsia

authors： Koch-Stoecker SC,Bien CG,Schulz R,May TW

更新日期：2017-06-01 00:00:00

abstract：:Successful treatment of hypothalamic hamartoma (HH) can result in the resolution of its sequelae including epilepsy and rage attacks. Risks and morbidity of open surgical management of this lesion have motivated the development of laser interstitial thermal therapy (LITT) as a less invasive treatment approach to the d...

journal_title：Epilepsia

authors： Du VX,Gandhi SV,Rekate HL,Mehta AD

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Lowering the length of stay (LOS) is thought to potentially decrease hospital costs and is a metric commonly used to manage capacity. Patients with epilepsy undergoing intracranial electrode monitoring may have longer LOS because the time to seizure is difficult to predict or control. This study investigates ...

journal_title：Epilepsia

authors： Chan AY,Kharrat S,Lundeen K,Mnatsakanyan L,Sazgar M,Sen-Gupta I,Lin JJ,Hsu FPK,Vadera S

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Nonadherence to prescribed dosing regimens is a significant problem in the treatment of pediatric and adult chronic epilepsy, and can result in severe consequences to patient outcomes. In this first-of-kind preclinical study, the impact of nonadherence on seizure control was studied by simulating human patter...

journal_title：Epilepsia

authors： Thomson KE,Modi AC,Glauser TA,Rausch JR,Steve White H

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Previous studies examining seizures in patients with 22q11.2 deletion syndrome (22q11.2DS) have focused primarily on children and adolescents. In this study we investigated the prevalence and characteristics of seizures and epilepsy in an adult 22q11.2DS population. METHODS:The medical records of 202 adult p...

journal_title：Epilepsia

authors： Wither RG,Borlot F,MacDonald A,Butcher NJ,Chow EWC,Bassett AS,Andrade DM

更新日期：2017-06-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common focal epilepsy in adults. TLE has a high chance of becoming medically refractory, and as such, is frequently considered for further evaluation and surgical intervention. Up to 30% of TLE cases, however, can have normal ("nonlesional" or negative) magnetic resonance imagi...

journal_title：Epilepsia

authors： Muhlhofer W,Tan YL,Mueller SG,Knowlton R

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:To identify features of ablations and trajectories that correlate with optimal seizure control and minimize the risk of neurocognitive deficits in patients undergoing laser interstitial thermal therapy (LiTT) for mesiotemporal epilepsy (mTLE). METHODS:Clinical and radiographic data were reviewed from a prosp...

journal_title：Epilepsia

authors： Jermakowicz WJ,Kanner AM,Sur S,Bermudez C,D'Haese PF,Kolcun JPG,Cajigas I,Li R,Millan C,Ribot R,Serrano EA,Velez N,Lowe MR,Rey GJ,Jagid JR

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:The International League Against Epilepsy (ILAE) has proposed to expand the definition of remission to 10 years seizure-free with the last 5 years off antiepileptic drugs (AEDs). We examined if a 10-year remission is needed to predict the lowest recurrence risk. METHODS:The population-based study cohort cons...

journal_title：Epilepsia

authors： Sillanpää M,Schmidt D,Saarinen MM,Shinnar S

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug-resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain understudied. We therefore investigated the expression and function of pregnane xenobiotic (PXR...

journal_title：Epilepsia

authors： Ghosh C,Hossain M,Solanki J,Najm IM,Marchi N,Janigro D

更新日期：2017-04-01 00:00:00

abstract：:Since it was originally described nearly 70 years ago, insular epilepsy has been increasingly recognized and may explain failures after apparently well-planned operations. We review the history of awareness of the phenomenon, techniques for its assessment, and its surgical management. Insular epilepsy can mimic featur...

journal_title：Epilepsia

authors： Laoprasert P,Ojemann JG,Handler MH

更新日期：2017-04-01 00:00:00

abstract：:The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure typ...

journal_title：Epilepsia

authors： Fisher RS,Cross JH,French JA,Higurashi N,Hirsch E,Jansen FE,Lagae L,Moshé SL,Peltola J,Roulet Perez E,Scheffer IE,Zuberi SM

更新日期：2017-04-01 00:00:00

abstract：:Drug-resistant epilepsy poses a challenge in neonatal patients, especially those in the neonatal intensive care unit (NICU), who have various secondary comorbidities. We present results of four children with a history of drug-resistant epilepsy for whom a ketogenic diet was initiated and used in the NICU. A nonfasting...

journal_title：Epilepsia

authors： Thompson L,Fecske E,Salim M,Hall A

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:In one third of patients, seizures remain after epilepsy surgery, meaning that improved preoperative evaluation methods are needed to identify the epileptogenic zone. A potential framework for such a method is network theory, as it can be applied to noninvasive recordings, even in the absence of epileptiform ...

journal_title：Epilepsia

authors： Nissen IA,Stam CJ,Reijneveld JC,van Straaten IE,Hendriks EJ,Baayen JC,De Witt Hamer PC,Idema S,Hillebrand A

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Epilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The chronic behavior of seizures and the interictal bursts that sometimes initiate them is unknown. We investigate the variability of these electrographic patterns over an extended period of time using chronic in...

journal_title：Epilepsia

authors： Ung H,Davis KA,Wulsin D,Wagenaar J,Fox E,McDonnell JJ,Patterson N,Vite CH,Worrell G,Litt B

更新日期：2016-12-01 00:00:00

abstract：:Many patients with medically refractory epilepsy now undergo successful surgery based on noninvasive diagnostic information, but intracranial electroencephalography (IEEG) continues to be used as increasingly complex cases are considered surgical candidates. The indications for IEEG and the modalities employed vary ac...

journal_title：Epilepsia

authors： Jayakar P,Gotman J,Harvey AS,Palmini A,Tassi L,Schomer D,Dubeau F,Bartolomei F,Yu A,Kršek P,Velis D,Kahane P

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Phenobarbital hypersensitivity is one of the common drug hypersensitivity syndromes in children. Clinical symptoms of phenobarbital hypersensitivity vary from maculopapular rashes (MPs) to severe cutaneous adverse drug reactions (SCARs) including drug reactions with eosinophilia and systemic symptoms (DRESS),...

journal_title：Epilepsia

authors： Manuyakorn W,Mahasirimongkol S,Likkasittipan P,Kamchaisatian W,Wattanapokayakit S,Inunchot W,Visudtibhan A,Wichukchinda N,Benjaponpitak S

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Posttraumatic epilepsy (PTE) accounts for 20% of acquired epilepsies. Experimental models are important for studying epileptogenesis. We previously reported that repetitive high-frequency oscillations with spikes (rHFOSs) occur early after lateral fluid percussion injury (FPI) and may be a biomarker for PTE. ...

journal_title：Epilepsia

authors： Reid AY,Bragin A,Giza CC,Staba RJ,Engel J Jr

更新日期：2016-10-01 00:00:00